ABSTRACT
This study examined the development of student mental health service provision by independent Christian schools in Ontario, Canada. Key informant interviews led to the development of three major themes-(i) Culture of Caring: A C hristian principle in action, (ii) Equifinality: multiple pathways to the same destination, and (iii) Normalizing Counselling: the creation of a positive feedback loop that was divided into five integrated stages. Three counselling models emerged to address students' psychosocial and emotional challenges. These programs were viewed as an extension of Christian ministry, holistically providing care within the school system not originally structured to meet such needs.
ABSTRACT
The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Recent curation work has expanded our annotations of normal and disease-associated signaling processes and of the drugs that target them, in particular infections caused by the SARS-CoV-1 and SARS-CoV-2 coronaviruses and the host response to infection. New tools support better simultaneous analysis of high-throughput data from multiple sources and the placement of understudied ('dark') proteins from analyzed datasets in the context of Reactome's manually curated pathways.